Adult 2 mg once daily. Geriatric >65 yr Initially 1 mg once daily & may be increased to 2 mg once daily.Severe renal impairment (GFR <30 mL/min/1.73 m2)1 mg once daily. Severe hepatic impairment (Child-Pugh class C) 1 mg once daily & may be increased to 2 mg once daily.
Hypersensitivity. Intestinal perforation or obstructive due to gut wall structural or functional disorder, obstructive ileus, severe inflammatory condition of GI tract (eg, Crohn's disease, ulcerative colitis, toxic megacolon/mega rectum). Renal impairment requiring dialysis.
Discontinue therapy if severe or persistent diarrhea; severe &/or worsening abdominal symptoms, bloody diarrhea, or rectal bleeding occur. History of arrhythmia, ischemic CV disease, pre-excitation syndromes (eg, Wolff-Parkinson-White syndrome) or AV nodal rhythm disorders. Patients w/ severe & unstable concomitant disease eg, cancer, AIDs, psychiatric, hepatic, pulmonary, insulin dependent DM. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption syndromes. May impair ability to drive & operate machinery. Severe hepatic impairment (Child-Pugh C). Renal impairment & patients requiring dialysis. Women of childbearing potential should use effective contraception during therapy. Not recommended during pregnancy & lactation. Not to be used in childn & adolescents <18 yr.
Sign Out
